- 简介
- 科研领域
- 学术发表
个人简介
刘富荣,北京大学现代农学院助理教授、研究员、博士生导师。博雅青年学者,国家级青年人才计划入选者. 2009年和2012年分别在西北农林科技大学获得学士和硕士学位,2018年毕业于美国加州大学戴维斯分校,获得植物病理学博士学位。博士毕业后,先后在加州大学戴维斯分校和加州大学伯克利分校从事博士后研究工作。研究成果发表在 Cell、Developmental Cell、The Plant Journal 等学术期刊。
教育经历
2012.08–2018.06,加州大学戴维斯分校(美国),植物病理学,博士
2009.09–2012.06,西北农林科技大学,植物病理学,硕士
2005.08–2009.07,西北农林科技大学,植物保护,学士
工作经历
2025.06–至今,北京大学现代农学院,研究员
2019.01–2020.06,2021.07–2025.05,加州大学伯克利分校(美国),博士后
2018.07-2018.12,加州大学戴维斯分校(美国),博士后
科研领域
实验室聚焦于水稻、小麦等重要作物中免疫受体识别病原信号与激活免疫反应的机制,结合结构生物学、遗传学、细胞生物学与分子互作组学等多学科手段,系统解析植物免疫的关键调控节点和信号传导网络。同时利用基因编辑技术培育广谱抗病作物品种,扩展病原识别范围,提升作物抗性精准化改造水平。
学术发表
Liu F, Staskawicz BJ. Wheat tandem kinase-NLR immune modules: Novel insights and engineering opportunities. Dev Cell. 2025 May 19;60(10):1398-1399. doi: 10.1016/j.devcel.2025.04.020. PMID: 40393392.
Liu F, Yang Z, Wang C, You Z, Martin R, Qiao W, Huang J, Jacob P, Dangl JL, Carette JE, Luan S, Nogales E, Staskawicz BJ. Activation of the helper NRC4 immune receptor forms a hexameric resistosome. Cell. 2024 Sep 5;187(18):4877-4889.e15. doi: 10.1016/j.cell.2024.07.013. Epub 2024 Aug 1. PMID: 39094568; PMCID: PMC11380581.
Tamborski J, Seong K, Liu F, Staskawicz BJ, Krasileva KV. Altering Specificity and Autoactivity of Plant Immune Receptors Sr33 and Sr50 Via a Rational Engineering Approach. Mol Plant Microbe Interact. 2023 Jul;36(7):434-446. doi: 10.1094/MPMI-07-22-0154-R. Epub 2023 Aug 14. PMID: 36867580; PMCID: PMC10561695.
Martin R, Liu F, Staskawicz B. Isolation of Protein Complexes from Tobacco Leaves by a Two-Step Tandem Affinity Purification. Curr Protoc. 2022 Oct;2(10):e572. doi: 10.1002/cpz1.572. PMID: 36205456.
Liu F, Chern M, Jain R, Martin JA, Schakwitz WS, Ronald PC. Silencing of Dicer-like protein 2a restores the resistance phenotype in the rice mutant, sxi4 (suppressor of Xa21-mediated immunity 4). Plant J. 2022 May;110(3):646-657. doi: 10.1111/tpj.15692. Epub 2022 Feb 21. PMID: 35106860.
Martin R, Qi T, Zhang H, Liu F, King M, Toth C, Nogales E, Staskawicz BJ. Structure of the activated ROQ1 resistosome directly recognizing the pathogen effector XopQ. Science. 2020 Dec 4;370(6521):eabd9993. doi: 10.1126/science.abd9993. PMID: 33273074; PMCID: PMC7995448.
Liu F, Zhang W, Schwessinger B, Wei T, Ruan D, Ronald P. The Rice Xa3 Gene Confers Resistance to Xanthomonas oryzae pv. oryzae in the Model Rice Kitaake Genetic Background. Front Plant Sci. 2020 Feb 6;11:49. doi: 10.3389/fpls.2020.00049. PMID: 32117387; PMCID: PMC7017783.
Liu F, McDonald M, Schwessinger B, Joe A, Pruitt R, Erickson T, Zhao X, Stewart V, Ronald PC. Variation and inheritance of the Xanthomonas raxX-raxSTAB gene cluster required for activation of XA21-mediated immunity. Mol Plant Pathol. 2019 May;20(5):656-672. doi: 10.1111/mpp.12783. Epub 2019 Feb 18. PMID: 30773771; PMCID: PMC6637879.
Pruitt RN, Schwessinger B, Joe A, Thomas N, Liu F, Albert M, Robinson MR, Chan LJ, Luu DD, Chen H, Bahar O, Daudi A, De Vleesschauwer D, Caddell D, Zhang W, Zhao X, Li X, Heazlewood JL, Ruan D, Majumder D, Chern M, Kalbacher H, Midha S, Patil PB, Sonti RV, Petzold CJ, Liu CC, Brodbelt JS, Felix G, Ronald PC. The rice immune receptor XA21 recognizes a tyrosine-sulfated protein from a Gram-negative bacterium. Sci Adv. 2015 Jul 24;1(6):e1500245. doi: 10.1126/sciadv.1500245. PMID: 26601222; PMCID: PMC4646787.