- 简介
- 科研领域
- 学术发表
个人简介
北京大学基因功能研究与操控全国重点实验室、现代农学院、北京大学-清华大学生命科学联合中心PI，博雅青年学者，博士生导师。中国遗传学会细胞遗传学分会委员，中国植物学会植物结构与生殖专委会委员。主持多项国家自然科学基金面上项目、作为骨干参与国家科技创新2030重大项目、入选国家级青年人才项目。近年来已发表论文32篇，其中以第一作者或通讯作者发表论文19篇，包括Nature Genetics、Molecular Cell、Genome Biology、Nature Communications、PNAS、Plant Cell等。目前实验室在读博士研究生10名。
教育经历
2010年毕业于北京生命科学研究所（NIBS）与兰州大学，获博士学位；
2011年起，先后在美国梅奥医学中心、德国马克斯普朗克植物育种学研究所进行博士后/博士后研究员工作。
工作经历
2018年9月入职北京大学现代农学院，同时加入蛋白质与植物基因研究国家重点实验室、北京大学-清华大学生命科学联合中心（CLS）。
科研领域
植物研究是农业科学的重要基石。本实验室致力于系统解析表观遗传调控在植物生长发育中的核心作用，重点围绕“表观遗传机制如何通过调控基因的时空特异性转录，进而控制植物发育”这一根本科学问题展开研究，旨在为作物遗传改良提供理论框架。调控植物发育的绝大多数关键基因均受到表观遗传修饰的精确控制。只有深入揭示表观遗传网络动态调控基因表达的机制，才能真正理解植物发育可塑性的分子基础，这也是实现精准分子育种的关键前提。目前，农业领域对植物表观遗传调控体系仍存在显著认知空白：从组蛋白修饰的动态机制、三维染色质结构的组织规律，到表观信息如何转化为基因时空表达模式，均亟待系统阐明。针对这一核心方向，本实验室聚焦于解析组蛋白修饰酶复合体的作用机制及其对染色质结构与基因转录的调控，并建立表观遗传动态变化与发育表型之间的分子网络。
学术发表
1. Zhang, Y., Huang, R., Yang, T., Li, A., Wang, Z., Wu, Y., Deng, Y., Zhang, J., He, XQ, Zhou, Y. PRC2 regulates cytokinin and HD-ZIP III pathways to orchestrate vascular tissue pattern formation in Arabidopsis. Plant Cell, 8:koaf194.
2. Xiao, S., Luo, L., Yang, M., He, H., Zhou, Y. Fine-scale 3D chromatin architectures and their regulatory mechanisms in plants. Curr Opin Plant Biol, doi.org/10.1016/j.pbi.2025.102786.
3. Luo, L., Yang, M., Song, Z., Liu, Y., Xiao, S., Wang, D., Calonje, M., He, H., Zhou, Y (2025). PRC1-Mediated H2Aub Loop Formation and Function in Arabidopsis. Adv Sci 12: e2304377.
4. Shu, J., Xiao, S., Wang, D., Yang, M., Zhou, Y (2025). Protocol for capturing genome-wide chromatin interactions in Arabidopsis. STAR Protoc 6: 103702.
5. Liu, Y., Xiao, S., Yang, M., Guo, G., Zhou, Y (2025). The Impact of Polycomb Group Proteins on 3D Chromatin Structure and Environmental Stresses in Plants. Plants (Basel) 14: 1308. (Invited review)
6. Luo, L., Yang, M., Zhou, Y (2025). BMI1s interact with condensin complexes to regulate chromatin 3D structure and gene expression in Arabidopsis. aBIOTECH, 10.1007/s42994-025-00202-x.
7. Song, Z., Xia, Q., Yang, M., Yang, T., Liu, Y., Wang, D., Shu, J., Liu, Z., Chi, Y., Xu, H., Xing, D., Zhou, Y (2025). Dynamic changes in 3D chromatin structure during male gametogenesis in Arabidopsis thaliana. Genome Biol 26: 27.
8. Wang, D., Xiao, S., Shu, J., Luo, L., Yang, M., Calonje, M., He, H., Song, B., Zhou, Y (2024). Promoter capture Hi‑C identifies promoter‑related loops and fountain structures in Arabidopsis. Genome Biol 25: 324.
9. Shu, J., Sun, L., Wang, D., Yin, X., Yang, M., Yang, Z., Gao, Z., He, Y., Calonje, M., Lai, J., Deng, X. W., He, H., Zhou, Y (2024). EMF1 functions as a 3D chromatin modulator in Arabidopsis. Mol Cell 84: 4729-4739.
10. Yang, T., Wang, D., Luo, L., Yin, X., Song, Z., Yang, M., Zhou, Y (2024). PWOs repress gene transcription by regulating chromatin structures in Arabidopsis. Nucleic Acids Res 52: 12918-12929.
11. Yin, X., Romero-Campero, F. J., Yang, M., Baile, F., Cao, Y., Shu, J., Luo, L., Wang, D., Sun, S., Yan, P., Gong, Z., Mo, X., Qin, G., Calonje, M., Zhou, Y (2023). Binding by the Polycomb complex component BMI1 and H2A monoubiquitination shape local and long-range interactions in the Arabidopsis genome. Plant Cell 35: 2484-2503.
12. Yang, T., Wang, D., Tian, G., Sun, L., Yang, M., Yin, X., Xiao, J., Sheng, Y., Zhu, D., He, H., Zhou, Y (2022). Chromatin remodeling complexes regulate genome architecture in Arabidopsis. Plant Cell 34: 2638-2651.
13. Yin, X., Romero-Campero, F. J., de los Reyes, P., Yan, P., Yang, J., Tian, G., Yang, X., Mo, X., Zhao, S., Calonje, M., Zhou, Y (2021). H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots. Nat Commun 12: 315.
14. Zhou, Y., Wang, Y., Krause, K., Yang, T., Dongus, JA., Zhang, Y., Turck, F (2018). Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nature Genet 50: 638-644.
15. Zhou, Y., Tergemina, E., Cui, H., Forderer, A., Hartwig, B., James, GV., Scheeberger, K., Turck, F (2017). Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Proc Natl Acad Sci U S A 114: 4833-4838.
16. Zhou, Y., Romero-Campero, FJ., Gomez-Zambrano, A., Turck, F., Calonje, M (2017). H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biol 16: 69.
17. Zhou, Y., Hartwig, B., James, GV., Schneeberger, K., Turck, F (2016). Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Plant Cell 28: 87-101.